Endocrine Abstracts

Introduction: Uterine leiomyoma (fibroid) is the most common solid tumor in reproductive-age women. Symptomatic leiomyomas affect millions of women through menorrhagia, abnormal uterine bleeding, and infertility. No effective treatment except surgery is available, partly because of the lack of effective animal models for screening new therapies. We established a new xenograft model by grafting primary cultured leiomyoma cells beneath the kidney capsule in super-immunodeficient...